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European Cells and Materials 41, 153169

You cannot overdose on B12 ( unlike many other vitamins and minerals ) This is a useful fact ( my doctor who refused me two-monthly injections said that an extra injection would be TOXIC

Furthermore, upregulation of voltage-gated Ca 2+ channels (VGCCs), particularly CaV1.3, promotes resistance to androgen deprivation therapy (ADT) and the progression of castration-resistant prostate cancer (CRPC) [32]