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It is chemically unstable, which means that it readily transforms into other sulfur-containing compounds spontaneously during cooking, aging, or as they are metabolized in the body

Although disulfide bonded ESSE can be reduced by GSH via thiol-disulfide exchange [220], it most commonly decomposes to ESH and a highly reactive sulfenic acid intermediate (ESOH) [221]

However, increased doses were associated with more adverse events, primarily gastrointestinal and cardiac or vascular in nature