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This can be from direct alkylation of cysteine residues in the bladder by the glutathione adduct or acrolein that is reformed in the bladder

These decisions will play a critical role in determining whether peptide therapies move closer to mainstream clinical use or remain in a more limited regulatory position

Cartilage faces even greater obstacles given avascular nature (no blood vessels penetrating tissue), low cell density (chondrocytes sparse within extensive extracellular matrix), minimal metabolic activity (slow turnover and repair), and mechanical loading challenges (constant stress impeding healing)