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CVD is a complex disease that involves multiple environmental and genetic factors, particularly atherosclerosis (AS), which mainly affects the large and middle arteries (3)

Because of the importance of these functions, the enzymes involved in NAD metabolism are targets for drug discovery

The phylogenetic relationship, gene duplication events, conserved motif composition, collinearity analysis, cis-acting elements, conserved domain, chromosomal localizations, non-synonymous, synonymous ratios, and functional divergence of these PavGST genes were all investigated in detail, providing insight into the functional diversity of GST families

In terms of the correlation between ferroptosis and autophagy, lipophagy [198] and the xCT autophagic degradation mediated by Beclin-1 [199] were found to trigger ferroptosis