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The combination therapy showed slightly better scores in WOMAC and Lequesne indices than HA alone, but not enough to support strong clinical superiority (Nouri et al., 2022)

These and other drugs co-used with tianeptine might all serve as starting points for additional work and greater awareness among medical professionals

Kynurenine production insufficiency theory Recent research has identified the aryl hydrocarbon receptor (AhR) and the enzyme indoleamine-2,3-dioxygenase (IDO) as key players in the increased gut permeability and bacterial endotoxin translocation seen in ME/CFS patients