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Human tau accumulation promotes glycogen synthase kinase-3 acetylation and thus upregulates the kinase: a vicious cycle in Alzheimer neurodegeneration

An effective FSP1 inhibitor (iFSP1) has been identified through a counter-screen of FSP1-overexpressing cells in a wild-type or GPX4 knockout setting, based on the strong protective effect of FSP1 on GPX4 knockout cells [4]

A randomized controlled trial on the effect of metformin in CHD patients without diabetes showed that it (2000 mg/day, P.O for 12 months) not only decreased oxidative stress but also lowered left ventricular mass (LVM) and improved blood pressure [227]

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