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receptor-mediated transcytosis occurs in three steps: receptor-mediated endocytosis of the agent at the luminal (blood) side, movement through the endothelial cytoplasm, and exocytosis of the drug at the abluminal (brain) side of the brain capillary endothelium

Statistical analysis Results were represented by mean standard deviation (SD)

In certain cancer types, including gastric, breast, renal clear cell, colorectal and endometrial cancer, and myeloid leukemia, the absence of GPX3 expression often indicates a poor prognosis and the development of resistance to chemotherapy in patients (2)

Quantification of proliferation and cell death To quantify cell proliferation, 300,000 cells were plated in 100 mm dishes and treated as specified