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Injections of vitamin B12 are commonly used to treat deficiencies, especially in cases where oral supplementation is ineffective due to absorption issues

In severe cases, adults may develop osteomalacia (soft bones), whilst children may develop rickets Fatigue and low mood : Persistent tiredness and depressive symptoms, though there is no official link definitively established between vitamin D levels and mood disorders Increased infection susceptibility : Some evidence suggests a link with recurrent respiratory infections, though clinical trial evidence is mixed and benefits appear modest Hair loss : Some observational studies have associated diffuse hair thinning with low vitamin D levels, though this relationship requires further research Vitamin B12 deficiency typically develops gradually and can cause significant neurological and haematological complications: Anaemia symptoms : Fatigue, pallor, shortness of breath, and palpitations due to megaloblastic anaemia Neurological manifestations : Paraesthesia (pins and needles), particularly in hands and feet

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PMC 5110436