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10.3390/foods11040617 166 XieY.MeijerA

Reactive metabolites (such as ROS and electrophiles) can promote adaptive responses through mitochondrial dysfunction, endoplasmic reticulum stress, or DNA damage, thereby increasing molecular chaperone proteins (Figure 3)

Furthermore, recent high-throughput sequencing data demonstrate the significance of these dysregulated signaling pathways in sustaining supportive TMEs that facilitate the growth and metastasis of numerous solid tumors (Wang et al., 2023)