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8.4 Gastrointestinal tract Pathogenic aggregates, p--Syn, fibrillar -Syn (f--Syn), or Lewy pathology have been found in the upper and lower gastrointestinal tracts of PD patients, with -Syn positive rates declining from proximal to distal

Giurato G, Terenzi I, Chiuso F, Salvati A, Rizzo F, Tarallo R, Weisz A, Nassa G

Moreover, high doses of L-Arg can induce the expression of arginases, which metabolizes L-Arg, and increase arginase activity is associated with eNOS uncoupling and endothelial dysfunction [122, 226, 227]

Institutional Review Board Statement All animal manipulations were made in accordance with the EU Directive 2010/63/EU for animal experiments