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Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells

Abstract Glutathione peroxidase 4 (GPX4), as the only enzyme in mammals capable of reducing esterified phospholipid hydroperoxides within a cellular context, protects cells from ferroptosis

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Nrf2, in turn, regulates the expression of GPx8 and affects calcium regulation in the endoplasmic reticulum through calcium ATPase (Granatiero et al