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In addition, combretastatin disrupts the endothelial cell junction molecule (VE-cadherin) leading to vascular collapse [45] and in vivo studies show that combretastatin is able to reduce immature vessels [45, 46]

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rubrum which was lower than that of the commercially used standard, fluconazole, having an MIC value of 11.43 mM (El-Zawawy and Ali 2016)