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Therapeutic strategies that modulate apoptosis may interfere with or promote regulated necrosis

Ling H, Pickard K, Ivan C, Isella C, Ikuo M, Mitter R, Spizzo R, Bullock MD, Braicu C, Pileczki V, Vincent K, Pichler M, Stiegelbauer V, Hoefler G, Almeida MI, Hsiao A, Zhang X, Primrose JN, Packham GK, Liu K, Bojja K, Gaf R, Xiao L, Rossi S, Song JH, Vannini I, Fanini F, Kopetz S , Zweidler-McKay P, Wang X, Ionescu C, Irimie A, Fabbri M, Lanza G, Hamilton SR, Berindan-Neagoe I, Medico E, Mirnezami AH, Calin GA, Nicoloso MS

Four-micron sections were cut from the paraffin blocks, and hematoxylineosin staining was administered

however, in KEAP1-mutated lung cancer cells, the upregulation of NRF2 results in increased FSP1 expression, thereby facilitating ferroptosis induction [101]