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As a xanthine derivative, istradefylline acts within the basal ganglia by selectively targeting adenosine A2A receptors, which influence output pathways involving glutamate and GABA, both of which are largely regulated independently of dopamine

doi: 10.1002/imt2.272 184 StepienMLopez-NoguerolesMLahozAKhnTPerlemuterGVoicanCet al

McGraw-Hill Medical, New York, pp 26112621 Hofman FM, Hinton DR, Johnson K, Merrill JE (1989) Tumor necrosis factor identified in multiple sclerosis brain