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the inventors also surprisingly found inhibitory activity with certain embodiments of the invention where R 1 is methyl with dual positional substitutions (see e.g., compounds 2j, 2m, 2k, and 2l, Table 2)

This drop may manifest as sluggishness, shortness of breath, or trouble staying focused on regular tasks

Likewise, IGF2 gene defects or imprinting defects cause severe fetal growth failure but somewhat less adverse effects on postnatal growth, more variable effects on brain development, and an absence of marked metabolic effects

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