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Cytokines, such as interleukins (ILs), interferons (IFNs), chemokines, tumor necrosis factors (TNFs), and transforming growth factor (TGF), are essential signaling molecules that play a central role in governing innate and adaptive immunity (214, 215)

This altered gut permeability may negatively affect DAO production and release, contributing to an imbalance in histamine levels and exacerbating histamine intolerance symptoms

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