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In this review, we summarize the updated achievements regarding the structure and biological function of ACSL4 and report how ACSL4-mediated ferroptosis and disordered lipid metabolism contribute to human diseases

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This work is supported by the Natural Products & Nanobiotechnology Research Lab, Saveetha Institute of Basic Medical Sciences (SIBMS), Saveetha Institute of Medical and Technical Sciences (SIMATS), (Saveetha University), Thandalam, Chennai, Tamil Nadu 602105, India Conflict of interest The author declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest