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Heme-regulated eIF2 kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis

[DOI] [PMC free article] [PubMed] [Google Scholar] 202.Greene NT and Shimizu KD, J

In extracellular Ca 2+ -depleted medium (Figure 2E) or in the presence of 100 M lanthanum ions (La 3+ ), a non-selective calcium channel blocker, tBuOOH-induced [Ca 2+ ] i accumulation was completely inhibited (not shown), suggesting the occurrence of Ca 2+ entries under oxidative conditions