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Alternatively, a study on subcellular distribution of EGT in hepatic cells 10 min after its intraperitoneal administration in rats revealed that 65% of injected EGT was found in cytoplasm, followed by mitochondria and microsomes with similar contents (~ 15%), and a trace amount in the nucleus (~ 3%) [89]

The mechanism operates on multiple levels simultaneously

This accumulation damages cellular membranes, impairs enzymatic function, and further suppresses the body's ability to heal, creating a self-perpetuating cycle of toxicity and immune dysfunction

A palmitoylation database also provides the opportunity to compare with other databases, leading for example to the generalized cross-talk between palmitoylation and ubiquitination