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SKU: 83877651321
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Description

Severe sepsis and septic shock

Saviano A, Apta B, Tull S, Pezhman L, Fatima A, Sevim M

Following subcutaneous injection in human studies: Bioavailability approaches 100% with subcutaneous administration Time to maximum plasma concentration (Tmax) occurs at approximately 1.0 hour (range 0.5-1.0 hours) Maximum plasma concentration (Cmax) averages 72.8 ng/mL Area under the curve (AUC) measures 276 hrng/mL The peptide exhibits relatively low plasma protein binding at 21% , allowing substantial free drug availability for central nervous system penetration