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Even though low mGPDH is associated with type 2 diabetes, disruption of the gene encoding it in mice does not impair GSIS, suggesting the malate/aspartate shuttle may compensate for the lack of glycerol-3-phosphate shuttle [25, 26]

Metabolomic studies Finally, four studies sought out to globally profile metabolic changes induced by high-dose VitC administration in breast, colorectal and hepatocellular cancer cell line models [32, 176,177,178]

Although data were not statistically significant, an increased exposition of band 3 was detected in human RBCs treated with 50 mM AAPH for 1 h at 37C with respect to untreated cells