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Slides were imaged and whole slides scanned using a Vectra Polaris Automated Quantitative Pathology Imaging System (Akoya Biosciences), and multispectral images were acquired using Phenochart software, version 1.0.12 (Akoya Biosciences) to unmix and remove autofluorescence

However, folate supplementation can mask these haematological changes whilst neurological damage continues, highlighting the importance of checking B12 status before commencing folate therapy

Volpe CMO, Villar-Delfino PH, Dos Anjos PMF, Nogueira-Machado JA

However, during CVS episodes the nausea (and possibly vomiting) is far more intense than it is between episodes