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ITPA Activity in Adults and Children Treated with or without Azathioprine: Relationship between TPMT Activity, Thiopurine Metabolites, and Co-medications

Heyer NJ, Echeverria D, Martin MD, et al

Reactive oxygen species (ROS) and dysregulated iron homeostasis promote oxidative stress and immune dysregulation through activation of the NF-B pathway, impairing macrophage phagocytic activity and contributing to resistance to ferroptosis (68)