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Ketamine is administered intravenously, but a derivative intranasal drug (esketamine [Ketanest]) has been approved for treating intractable depression

Direct human evidence for the KLOW combination does not exist

Highly BBB-permeable Bs are less selective for 1 ARs (Table 1), which raises the possibility that the observed Alzheimer's risk reduction is driven by increased 2 AR inhibition rather than higher BBB permeability