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Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway

First, circadian disruption and inflammation have been linked to these diseases independently

SYMPTOMS Redness, foreign body sensation, pain, light sensitivity, discharge, mild to severe decreased vision

Magnetic resonance imaging (MRI) and computed tomography (CT) are alternative options, though they do not reliably capture the full histopathologic spectrum of NAFLD