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Brisson BK, Spinazzola J, Park S, Barton ER

The pMET protein levels peak at P7P14 in the neocortex, a period corresponding to synaptogenesis and dendritic outgrowth, and are downregulated during the 3rd post-natal week, between P14 and P17, when pruning and functional synapse maturation occur (Eagleson et al., 2016)

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They proposed that the interaction between BMAL1:CLOCK and E-box sequences in gene promoters could potentially modulate the recruitment and activity of HIF-1 at HRE sites located near or partially overlapping with E-box sequences, thereby effectively regulating the expression of its target genes