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Disorders ruled-out included generalized hyperlipidemia, hypercholesterolemia, multiple carboxylase deficiencies (that is, biotinidase deficiency), zinc deficiency, abnormal copper metabolism and hypoglycemia

The "bacteriostatic" designation refers to the preservative's function: benzyl alcohol inhibits bacterial growth without necessarily killing bacteria outright, which allows the water to be withdrawn from a multi-use vial multiple times over an extended period without significant microbial contamination

The Staphylococcus aureus and Streptococcus toxins are another example of a target polypeptide that can be altered using the methods of the invention

The PICALM protein plays a key role in iron homeostasis and cell proliferation