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Therapeutic intervention may involve the use of renin-angiotensin system (RAS) blockers to inhibit the vasoconstrictive effect of angiotensin II at the vas efferens or sodium-glucose co-transporter-2 (SGLT2) inhibitors, constricting the afferent arteriole, thereby reducing the burden of excessively filtered molecules in the proximal tubule (e.g., albumin, glucose and phosphate) [34]

NTR1 activation enhances neuronal excitability and improves spatial learning ability and memory in APP/PS1 transgenic mice [66]

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Winner et al., 2011)