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On the correct handling of best-before dates and use-by dates

If the mutation arose only once to a single common ancestor supporting the scenario of a founder mutation, the neighbour segments of the chromosome of nowadays patients carrying the R254X mutation should be descended from this common ancestor and thus identical among nowadays patients

Figure 6 7 Mental health disorders in cirrhosis 7.1 Prevalence and characteristics Mental health disorders leading to poor quality of life and emotional distress profoundly impact patients with cirrhosis, leading to increasing severity of symptoms related to liver disease, advanced histological abnormalities, increased mortality rates, and poor adherence to medical treatments (40)