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Dysfunctional mitochondria generate excessive ROS, mtDNA instability, and oncogenic signaling

History of the ketogenic diet

Well, either dog found a bone and left you alone or you're able to dodge the dog and you find a place and literally the stress goes away once the dog stopped chasing you

The growth-promoting effects of growth hormone include muscle tissue hypertrophy (which may be desired by some but represents an anabolic effect), bone growth and remodeling (problematic after growth plates close), organ enlargement with chronic supraphysiologic doses (cardiac hypertrophy, acromegaly features), connective tissue proliferation (potentially contributing to joint pain and carpal tunnel syndrome), and cellular proliferation that may support tumor growth in susceptible individuals