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The succinylation of PGK1 disrupts the integrity of the blood-brain barrier by modulating the angiostatin/VEGF pathway, leading to alterations in seizure activity (183)

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In support, intravenous or intravitreous L-NAME application, given before, would aggravate the harmful effect of the major noxious procedure (i.e., ischemia by increasing intraocular pressure above systolic pressure by the infusion into the anterior chamber