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The examination included collecting anamnesis (including taking urate-lowering drugs (ULD) and colchicine), anthropometric data (height, weight, BMI), determining the level of pain in knee joints using a visual analogue scale (VAS), blood test for UA levels, and performing radiography (TeleCord MT Plus device, Russia) of the knees joints to determine the radiological stage of OA according to Kellgren-Lawrence

Reproductive toxicity studies of acetylcysteine solution in the rat given oral doses of acetylcysteine solution up to 1,000 mg/kg (5.2 times the human mucolytic dose) have also been reported in the literature.1 The only adverse effect observed was a slight non-dose-related reduction in fertility at dose levels of 500 or 1,000 mg/kg/day (2.6 or 5.2 times the human mucolytic dose) in the Segment I study

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