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E.WolfeR

Besides the cytotoxicity pathways discussed above, Se-induced cytotoxicity against malignant cells might also be the result of ROS generation, as in the case of injection of biogenic SeNPs into the abdominal cavity of mice following their inoculation with highly malignant H22 hepatocarcinoma cells [294]

Biomedicines 10:2236

Furthermore, the key ferroptosis regulatory inhibitor GPX4 of the antioxidant system and its upstream regulatory target GSH expression were suppressed, and the cytotoxicity of EMFF against granulosa cells could be attenuated by an iron chelator and ferroptosis inhibitor but not by the apoptosis, necrosis, and autophagy inhibitor