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Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, et al

Effect sizes The UPDRS is a cumulative severity scale in which higher scores represent greater motor and non-motor impairment, therefore, reductions in total or subscale scores reflect clinical improvement, while increases indicate worsening of symptoms

Neurotoxin-based models of Parkinsons disease

Little synthesis of 26(27)hydroxycholesterol occurs in brain (mainly from alveolar macrophages), but some diffuses across the blood-brain barrier from the blood stream into the brain (in the reverse direction to 24hydroxycholesterol), where it does not accumulate but is further oxidized and then exported as steroidal acids