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K., Shor-Posner, G., Lu, Y, et al

How aging influences the gut-bone marrow axis and alters hematopoietic stem cell regulation

One area of ongoing debate is whether persistent symptoms reflect ongoing infection, residual tissue injury, immune dysregulation, untreated co-infections, autonomic dysfunction, or a combination of these factors

Other pieces of BD pathogenesis, including inflammation, mitochondrial dysfunction, calcium dysregulation, neurotransmission disturbance, and affection of synaptic plasticity and myelination, are either a preface or an aftermath of iron dysregulation