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Oxidative stress activates multiple transcription factors, including hypoxia-inducible factor-1 (HIF-1), AP-1, NF-B, p53, and nuclear factor erythroid 2-related factor 2 (Nrf2) (Reuter et al., 2010)

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Data extracted from each study were as follows: the surname of first author, year of publication, country and ethnicity of the subjects, case number and control number with the GSTT1 null, number of total subjects, source of control, genotyping method, and case confirmation approach