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Adoption of harmonized product characterization and core mechanistic panels (e.g., SCFAs, bile acids, barrier/immune biomarkers) would materially improve evidence synthesis and regulatory appraisal

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3.11 Histopathology of hippocampus of rat brain The examination of a section of the cerebral cortex stained with hematoxylin and eosin (H&E) reveals several critical observations: (A) Cortical neurons () characterized by rounded vesicular nuclei (yellow ) display sharply demarcated nuclear contours, while blood vessels (v) are accompanied by a narrow perivascular space indicative of degenerated and shrunken neurons

Future research should therefore focus on unraveling the cellular and molecular pathways through which heat stress alters immune function, including detailed analysis of signaling cascades involved in immunity and disease resistance