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Likewise, acriflavine, an antibacterial drug that was clinically used before penicillin, was noticed to directly bind to the HIF-1 and HIF-2 PAS-B subdomain and prevents them from interacting with HIF-1, preventing the transcription of genes controlled by HIF and impairing the development and vascularization of the tumor [99,100,101]

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During 2009 a total of 69 samples were analyzed of which 31.9% had the CVMNK haplotype whereas 68.1% were CVIET