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CBP/p300 (described in Section 3.2) and murine double minute-2 (MDM2), respectively, are positive and negative regulators that bind to sites on the N-terminal region of p53 ( TP53 mutations frequently occur in the DNA-binding domain, thereby disrupting the function of the p53 protein and its downstream network ( FIGURE 3 Under normal physiological conditions, p53 is a housekeeping protein with a short half-life ( 3.2 Post-Translational Modifications of p53 and Their Impacts on p53-Mediated Ferroptosis The paradigm shift concerning the role of p53 in ferroptosis prompted us to investigate how and when p53 promotes or suppresses ferroptosis

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(PubMed) Hu Y, Feng W, Chen H, et al