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doi:10.1016/j.neurot.2024.e00350

Pro- and antiangiogenic therapies: current status and clinical implications

Definition: CAIs are a class of diuretics that inhibit the enzyme carbonic anhydrase found primarily in the proximal convoluted tubule of the nephron, not first-line diuretics for hypertension or heart failure due to their weak natriuretic effect Mechanism of Action: They block carbonic anhydrase, which reduces the reabsorption of bicarbonate (HCO), sodium (Na), and water, leading to increased diuresis and alkaline urine

Following treatment with Melanotan 2, these autism-like behaviors were notably reduced, suggesting a potential role for the peptide in research into oxytocin-related pathways