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Furthermore, excessive expression of MRM3 might disrupt mitochondrial quality control mechanisms, such as autophagy and protein degradation, potentially harming mitochondrial health and function and increasing the risk of DKA

24,25,26 The major difference between the 2 COX enzymes is that while COX-1 is more or less ubiquitously and constitutively expressed, COX-2 is an inducible enzyme, 26,27,28 albeit with some important exceptions