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Carcinogenicity studies on 1,2-dibromoethane Route Species Number of animals Sex a Dose and dosing schedule b Duration c Reference (strain) per group Gavage Mouse 50 M 62 mg/kg body weight TWA d 78 weeks(53) NCI (1978) (B6C3F 1 ) (treated) 107 mg/kg body weight TWA d 77 weeks(53) F 62 mg/kg body weight TWA d 90 weeks(53) 107 mg/kg body weight TWA d 78 weeks(53) 20 M,F (control) e Rat 50 M 38 mg/kg body weight TWA d 49 weeks(47) NCI (1978) (Osborn- (treated) 41 mg/kg body weight TWA d 49 weeks(34) Mendel) F 37 mg/kg body weight TWA d 61 weeks(57) 39 mg/kg body weight TWA d 61 weeks(44) 20 M,F (control) e Drinking-water Mouse 30 M 117 mg/kg body weight per day 15 months Van Duuren et (B6C3F 1 ) (treated) F 103 mg/kg body weight per day 17 months al

doi: 10.1016/j.jtemb.2019.01.002 140 CoskunAArikanTKilincMArikanDCEkerbierH

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