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This dosage showed the potential to trigger an elevation in the number of mitochondria and upregulation in the expression of the Ucp2 gene, which has a crucial role in regulating the mitochondrial processes associated with energy balance to prevent excessive weight gain

NADPH oxidase, NOX

doi: 10.3390/cancers14215206

Evidence suggests that Nurr1 and Pitx3 cooperate to regulate the expression of DA neurotrophic factors such as brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor, as well as genes critical for DA neurotransmission, thereby promoting VTA DA neuron survival and the acquisition of mature DA phenotypes (Hegarty et al., 2013