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Irradiation and Drug Treatments X-ray irradiation was performed at room temperature with X-RAD 320 X-Ray Biological Irradiator (Precision X-ray, North Branford, CT, USA) using 320 kV, 12.5 mA, a 1.65 mm aluminum filter and a dose rate of 3.40 Gy/min with the cells in a distance of 50 cm were or the X-ray generator ISO-DEBYEFLEXVOLT 3003 with an industrial X-ray tube 160 M1/10-55 with installed shutter (15b) operated at 35kV and 80mA (GE Sensing & Inspection Technologies GmbH & Co.KG, Ahrensburg, Germany)

Therefore, the identification of novel senescence reversal factors is needed