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Other possible sources for MG formation include the auto-oxidation of surgars, as well as the metabolism of acetone and aminoacetone ( FIGURE 1 MG Detoxification in Plants via Glyoxalase and Other Metabolic Pathways Methylglyoxal detoxification involves the conversion of MG to less toxic molecules, thus limiting its detrimental effects

These molecules aid clearance of the damaged tissue but can also induce harm to healthy surrounding tissue ( As shown, muscle injury evoked by exercise is a complex response including multiple cells and multiple molecules (Figure 1)

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demonstrated that OS triggers DNA methyltransferase 1 (DNMT1)-dependent methylation of ALDH promoters, resulting in decreased ALDH expression and -alanine synthesis and reducing carnosine availability