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doi: 10.1016/j.trecan.2021.02.004 Summary Keywords metabolic reprogramming, phosphoglycerate dehydrogenase (PHGDH), serine metabolism, serine synthesis pathway (SSP), targeted therapy, tumor immune microenvironment Citation Su P, Yang Y and Zheng H (2026) The serine code of metabolic reprogramming: multidimensional roles of the serine synthesis pathway in tumors and novel breakthroughs for targeted therapy