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In patients with Alzheimers disease, lower plasma levels of -, -, -, and -tocopherol, as well as tocotrienols, were associated with poorer cognitive function and elevated oxidative stress markers [55]

(d) promoting antioxidant molecules and the expression of related genes involved in mitochondrial energy biogenesis, mainly through AMPK/SIRT1/Nrf2, ERK/p38 Mitogen-activated protein kinase (MAPK), and PTEN/Akt signaling pathways