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With careful augmentation of different antidepressants and other treatment modalities, about 910% of patients with depression have treatment-resistant depression ( In this scenario, several research groups have intensified their search for new antidepressants, including psychedelic substances (Santos et al., 2016)

Such recommendations often involve modifying eating behaviors and increasing physical activity to reduce net caloric intake

Similarly, preclinical research involving animals must comply with the directives of the Institutional Animal Care and Use Committee (IACUC), adhering to the standards delineated by the Animal Welfare Act (AWA)

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