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doi: 10.1128/JVI.03678-13 176 AkaikeTMaedaH

Han Y, Chu X, Cui L, et al

The lipophilic nature of curcumin is collectively attributed to its nonpolar methyl groups, aromatic rings, and aliphatic bridge (81)

Samples from 44 individuals with melanoma following anti-PD-1 treatment were subjected to clustered regularly interspaced short palindromic repeats (CRISPR) screenings of tumor cells escaping PD-1 blockade, and approximately 25% of the resistant tumors exhibited genetic alterations in B2M and the janus tyrosine kinase 1/2-signal transducer and activator of transcription (JAK1/2-STAT) signaling pathways [98]