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Such considerations conceivably may contribute to the known greater neurotoxicity of A42 small oligomers relative to those of A40 (126)

This leads us to our next critical topic

20 Subsequently, several case series described good outcomes for patients with acetaminophen overdose who were treated on the basis of the presence of a toxic blood concentration with either intravenous 21 , 22 or oral 6 , 23 25 acetylcysteine